Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

30 Apr 2018 Starke Ilka Glick Gary D. Börsch Michael

Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and induces apoptosis via increased reactive oxygen production in coupled, actively respiring mitochondria... (read more)

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