Another UNet is utilized to acquire primary segmentation.
Deep Learning (DL) approaches have been providing state-of-the-art performance in different modalities in the field of medical imagining including Digital Pathology Image Analysis (DPIA).
Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by: (1) noisy and expensive reference standards established by pathologists, (2) lack of generalization due to staining variation across laboratories, and (3) high computational requirements needed to process gigapixel whole-slide images (WSIs).
In this paper, we present a semi-supervised mitosis detection method which is designed to leverage a large number of unlabeled breast cancer WSIs.
The best performing automatic method for the first task achieved a quadratic-weighted Cohen's kappa score of $\kappa$ = 0. 567, 95% CI [0. 464, 0. 671] between the predicted scores and the ground truth.
We have attempted to replicate the main method in 'Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs' published in JAMA 2016; 316(22).
Preparing and scanning histopathology slides consists of several steps, each with a multitude of parameters.
A statistical analysis of these measurements requires annotation of mitosis events, which is currently a tedious and time-consuming task that has to be performed manually.
The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers.