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Automated detection and quantification of COVID-19 airspace disease on chest radiographs: A novel approach achieving radiologist-level performance using a CNN trained on digital reconstructed radiographs (DRRs) from CT-based ground-truth
Purpose: To leverage volumetric quantification of airspace disease (AD) derived from a superior modality (CT) serving as ground truth, projected onto digitally reconstructed radiographs (DRRs) to: 1) train a convolutional neural network to quantify airspace disease on paired CXRs; and 2) compare the DRR-trained CNN to expert human readers in the CXR evaluation of patients with confirmed COVID-19.
Quantifying and Leveraging Predictive Uncertainty for Medical Image Assessment
In our experiments we demonstrate that sample rejection based on the predicted uncertainty can significantly improve the ROC-AUC for various tasks, e. g., by 8% to 0. 91 with an expected rejection rate of under 25% for the classification of different abnormalities in chest radiographs.
3D Tomographic Pattern Synthesis for Enhancing the Quantification of COVID-19
Additionally, we leverage location priors derived from manually labeled COVID-19 chest CTs patients to generate appropriate abnormality distributions.
Automated Quantification of CT Patterns Associated with COVID-19 from Chest CT
Automated processing time to compute the severity scores was 10 seconds per case compared to 30 minutes required for manual annotations.
