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Anti-seizure medication tapering is associated with delta band power reduction in a dose, region and time-dependent manner
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice.
Diminished circadian and ultradian rhythms in pathological brain tissue in human in vivo
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain.
Complementary structural and functional abnormalities to localise epileptogenic tissue
Here, we investigate whether structural connectivity abnormalities, inferred from dMRI, may be used in conjunction with functional iEEG abnormalities to aid localisation and resection of the epileptogenic zone (EZ), and improve surgical outcomes in epilepsy.
Temporal stability of intracranial EEG abnormality maps for localising epileptogenic tissue
To assess the localising value of band power abnormality, we computed DRS - a measure of how different the surgically resected and spared tissue were in terms of band power abnormalities - over time.
Normative brain mapping of interictal intracranial EEG to localise epileptogenic tissue
We then compared interictal recordings from 62 patients with epilepsy to the normative map to identify abnormal regions.
