Unsupervised ensemble-based phenotyping helps enhance the discoverability of genes related to heart morphology

no code implementations • 7 Jan 2023 • Rodrigo Bonazzola, Enzo Ferrante, Nishant Ravikumar, Yan Xia, Bernard Keavney, Sven Plein, Tanveer Syeda-Mahmood, Alejandro F Frangi

Here, we propose a new framework for gene discovery entitled Unsupervised Phenotype Ensembles (UPE).

Discovery methods for systematic analysis of causal molecular networks in modern omics datasets

no code implementations • 28 Jan 2022 • Jack Kelly, Carlo Berzuini, Bernard Keavney, Maciej Tomaszewski, Hui Guo

With the increasing availability and size of multi-omics datasets, investigating the casual relationships between molecular phenotypes has become an important aspect of exploring underlying biology and genetics.