MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles

1 code implementation • 8 Aug 2023 • Hiba Kobeissi, Javiera Jilberto, M. Çağatay Karakan, Xining Gao, Samuel J. DePalma, Shoshana L. Das, Lani Quach, Jonathan Urquia, Brendon M. Baker, Christopher S. Chen, David Nordsletten, Emma Lejeune

With this manuscript, we disseminate "MicroBundleCompute" as an open-source computational tool with the aim of making automated quantitative analysis of beating cardiac microbundles more accessible to the community.

Drug Discovery

A Data-Driven Computational Model for Engineered Cardiac Microtissues

no code implementations • 31 May 2023 • Javiera Jilberto, Samuel J. DePalma, Jason Lo, Hiba Kobeissi, Lani Quach, Emma Lejeune, Brendon M. Baker, David Nordsletten

We use this experimental and modeling pipeline to study different mechanical environments, where we contrast the force output of the tissue with the computed active stress of CMs.