no code implementations • 26 May 2023 • Kadina E. Johnston, Clara Fannjiang, Bruce J. Wittmann, Brian L. Hie, Kevin K. Yang, Zachary Wu
Directed evolution of proteins has been the most effective method for protein engineering.
no code implementations • bioRxiv 2022 • Christian Dallago, Jody Mou, Kadina E. Johnston, Bruce J. Wittmann, Nicholas Bhattacharya, Samuel Goldman, Ali Madani, Kevin K. Yang
Machine learning could enable an unprecedented level of control in protein engineering for therapeutic and industrial applications.
no code implementations • 19 Feb 2019 • Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, Frances H. Arnold
To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning in the directed evolution workflow.
Biomolecules