no code implementations • 16 Aug 2023 • Carsten Conradi, Maya Mincheva
Hence we argue that in distributive double phosphorylation (sequential or distributive) the catalytic constants enable non-trivial dynamics.
1 code implementation • 31 Oct 2019 • Carsten Conradi, Nida Obatake, Anne Shiu, Xiaoxian Tang
We consider a model of extracellular signal-regulated kinase (ERK) regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but loses these properties in the limit in which the mechanisms underlying phosphorylation and dephosphorylation become processive.
