Search Results for author: Catherine A. A. Beauchemin

Found 5 papers, 2 papers with code

Stochastic failure of cell infection post viral entry: Implications for infection outcomes and antiviral therapy

1 code implementation1 Aug 2022 Christian Quirouette, Daniel Cresta, Jizhou Li, Kathleen P. Wilkie, Haozhao Liang, Catherine A. A. Beauchemin

We show that infections wherein virus is release by an infected cell as a single burst, rather than at a constant rate over the cell's infectious lifespan, has the same probability of infection extinction, despite previous claims to this effect [Pearson 2011, doi:10. 1371/journal. pcbi. 1001058].

Quantifying the relative contribution of free virus and cell-to-cell transmission routes to the propagation of hepatitis C virus infections in vitro using an agent-based model

no code implementations10 Feb 2021 Kenneth Blahut, Christian Quirouette, Jordan J. Feld, Shingo Iwami, Catherine A. A. Beauchemin

Experiments have shown that hepatitis C virus (HCV) infections in vitro disseminate both distally via the release and diffusion of cell-free virus through the medium, and locally via direct, cell-to-cell transmission.

Quantification of Ebola virus replication kinetics in vitro

no code implementations19 Oct 2020 Laura E. Liao, Jonathan Carruthers, Sophie J. Smither, CL4 Virology Team, Simon A. Weller, Diane Williamson, Thomas R. Laws, Isabel Garcia-Dorival, Julian Hiscox, Benjamin P. Holder, Catherine A. A. Beauchemin, Alan S. Perelson, Martin Lopez-Garcia, Grant Lythe, John Barr, Carmen Molina-Paris

Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilities for experimentation, modelling can play a crucial role.

Bayesian Inference

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

1 code implementation22 Aug 2019 Christian Quirouette, Nada P. Younis, Micaela B. Reddy, Catherine A. A. Beauchemin

The MM herein represents the HRT as a one-dimensional track extending from the nose down to a depth of 30 cm, wherein stationary cells interact with the concentration of IAV which move along within the PCF.

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