no code implementations • 29 May 2020 • David J. Smith, Alessandro Prete, Angela E. Taylor, Niki Karavitaki, Wiebke Arlt
A simplified mathematical model of oral hydrocortisone delivery in adrenal insufficiency is described; the model is based on three components (gastric hydrocortisone, free serum cortisol and bound serum cortisol) and is formulated in terms of linear kinetics, taking into account the dynamics of glucocorticoid-protein binding.