no code implementations • 21 Apr 2024 • Xiaoyu Wang, Ryan P. Kelly, David J. Warne, Christopher Drovandi
To overcome this, we propose preconditioned NPE (PNPE) and its sequential version (PSNPE), which uses a short run of ABC to effectively eliminate regions of parameter space that produce large discrepancy between simulations and data and allow the posterior emulator to be more accurately trained.
no code implementations • 31 Jan 2023 • Ryan P. Kelly, David J. Nott, David T. Frazier, David J. Warne, Chris Drovandi
Simulation-based inference techniques are indispensable for parameter estimation of mechanistic and simulable models with intractable likelihoods.
1 code implementation • 28 Dec 2019 • David J. Warne, Ruth E. Baker, Matthew J. Simpson
For many stochastic models of interest in systems biology, such as those describing biochemical reaction networks, exact quantification of parameter uncertainty through statistical inference is intractable.
1 code implementation • 14 Sep 2019 • David J. Warne, Ruth E. Baker, Matthew J. Simpson
In this work, we present new computational Bayesian techniques that accelerate inference for expensive stochastic models by using computationally inexpensive approximations to inform feasible regions in parameter space, and through learning transforms that adjust the biased approximate inferences to closer represent the correct inferences under the expensive stochastic model.
Computation Cell Behavior Molecular Networks
1 code implementation • 25 Feb 2019 • David J. Warne, Scott A. Sisson, Christopher Drovandi
We illustrate the potential of SIMD for accelerating Bayesian computations and provide the reader with techniques for exploiting modern massively parallel processing environments using standard tools.
1 code implementation • 14 Dec 2018 • David J. Warne, Ruth E. Baker, Matthew J. Simpson
Stochasticity is a key characteristic of intracellular processes such as gene regulation and chemical signalling.
Molecular Networks