Search Results for author: David J. Warne

Found 6 papers, 4 papers with code

Preconditioned Neural Posterior Estimation for Likelihood-free Inference

no code implementations21 Apr 2024 Xiaoyu Wang, Ryan P. Kelly, David J. Warne, Christopher Drovandi

To overcome this, we propose preconditioned NPE (PNPE) and its sequential version (PSNPE), which uses a short run of ABC to effectively eliminate regions of parameter space that produce large discrepancy between simulations and data and allow the posterior emulator to be more accurately trained.

Misspecification-robust Sequential Neural Likelihood for Simulation-based Inference

no code implementations31 Jan 2023 Ryan P. Kelly, David J. Nott, David T. Frazier, David J. Warne, Chris Drovandi

Simulation-based inference techniques are indispensable for parameter estimation of mechanistic and simulable models with intractable likelihoods.

Uncertainty Quantification

A practical guide to pseudo-marginal methods for computational inference in systems biology

1 code implementation28 Dec 2019 David J. Warne, Ruth E. Baker, Matthew J. Simpson

For many stochastic models of interest in systems biology, such as those describing biochemical reaction networks, exact quantification of parameter uncertainty through statistical inference is intractable.

Uncertainty Quantification

Rapid Bayesian inference for expensive stochastic models

1 code implementation14 Sep 2019 David J. Warne, Ruth E. Baker, Matthew J. Simpson

In this work, we present new computational Bayesian techniques that accelerate inference for expensive stochastic models by using computationally inexpensive approximations to inform feasible regions in parameter space, and through learning transforms that adjust the biased approximate inferences to closer represent the correct inferences under the expensive stochastic model.

Computation Cell Behavior Molecular Networks

Vector operations for accelerating expensive Bayesian computations -- a tutorial guide

1 code implementation25 Feb 2019 David J. Warne, Scott A. Sisson, Christopher Drovandi

We illustrate the potential of SIMD for accelerating Bayesian computations and provide the reader with techniques for exploiting modern massively parallel processing environments using standard tools.

Distributed Computing

Simulation and inference algorithms for stochastic biochemical reaction networks: from basic concepts to state-of-the-art

1 code implementation14 Dec 2018 David J. Warne, Ruth E. Baker, Matthew J. Simpson

Stochasticity is a key characteristic of intracellular processes such as gene regulation and chemical signalling.

Molecular Networks

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