A single-cell RNA expression map of coronavirus receptors and associated factors in developing human embryos

no code implementations • 10 Apr 2020 • Stacy Colaco, Karisma Chhabria, Domdatt Singh, Anshul Bhide, Neha Singh, Abhishek Singh, Atahar Husein, Anuradha Mishra, Richa Sharma, Nancy Ashary, Deepak Modi

To predict if developing human embryos are permissive to coronaviruses, we analyzed publicly available single cell RNA-seq datasets of zygotes, 4-cell, 8-cell, morula, inner cell mass, epiblast, primitive endoderm and trophectoderm for the coronavirus receptors (ACE2, BSG, DPP4 and ANPEP), the Spike protein cleavage enzymes (TMPRSS2, CTSL).

Management