Search Results for author: Edmund J. Crampin

Found 4 papers, 2 papers with code

Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis

1 code implementation9 May 2022 Domenic P. J. Germano, Stuart T. Johnston, Edmund J. Crampin, James M. Osborne

We also demonstrate the model's robustness under tissue renewal, cell migration and cell removal.

Ca2+ release via IP3 receptors shapes the cytosolic Ca2+ transient for hypertrophic signalling in ventricular cardiomyocytes

no code implementations13 Feb 2019 Hilary Hunt, Agne Tilunaite, Greg Bass, Christian Soeller, H. Llewelyn Roderick, Vijay Rajagopal, Edmund J. Crampin

When coupled to a model of downstream transcription factor (NFAT) activation, we demonstrate that there is a high correspondence between the Ca transient duty cycle and the proportion of activated NFAT in the nucleus.

A thermodynamic framework for modelling membrane transporters

1 code implementation12 Jun 2018 Michael Pan, Peter J. Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J. Crampin

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell membranes.

Biomolecules

Gene expression modelling across multiple cell-lines with MapReduce

no code implementations21 Jul 2015 David M. Budden, Edmund J. Crampin

With the wealth of high-throughput sequencing data generated by recent large-scale consortia, predictive gene expression modelling has become an important tool for integrative analysis of transcriptomic and epigenetic data.

Computational Efficiency

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