no code implementations • 10 Feb 2024 • Mattia Miotto, Lorenzo Di Rienzo, Leonardo Bo', Giancarlo Ruocco, Edoardo Milanetti
Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic of protein-protein binding regions, and it is critical in influencing the stability of the complex.
no code implementations • 8 May 2023 • Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Enhanced stabilisation of protein structures via the presence of inert excipients is a key mechanism adopted both by physiological systems and in biotechnological applications.
no code implementations • 21 Aug 2022 • Greta Grassmann, Lorenzo Di Rienzo, Giorgio Gosti, Marco Leonetti, Giancarlo Ruocco, Mattia Miotto, Edoardo Milanetti
Understanding the molecular mechanisms driving the binding between bio-molecules is a crucial challenge in molecular biology.
no code implementations • 13 Sep 2021 • Michele Monti, Jonathan Fiorentino, Edoardo Milanetti, Giorgio Gosti, Gian Gaetano Tartaglia
We show that the prediction is extremely accurate for GRNs with different architectures.
no code implementations • 15 Jul 2021 • Alfredo De Lauro, Lorenzo Di Rienzo, Mattia Miotto, Pier Paolo Olimpieri, Edoardo Milanetti, Giancarlo Ruocco
We developed a Monte Carlo procedure to increase the shape complementarity between the antibody paratope and a given epitope on a target protein surface.
no code implementations • 14 Jul 2020 • Mattia Miotto, Lorenzo Di Rienzo, Leonardo Bò, Alberto Boffi, Giancarlo Ruocco, Edoardo Milanetti
Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capability, and a surprisingly high viral charge of symptom-less people.
no code implementations • 30 Mar 2020 • Andrea Vandelli, Michele Monti, Edoardo Milanetti, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Specific elements of viral genomes regulate interactions within host cells.