An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination

no code implementations • 7 Jan 2021 • Ziyu Gao, Xuebin Yang, Elena Jones, Paul A. Bingham, Alex Scrimshire, Paul D. Thornton, Giuseppe Tronci

Regulating the activity of matrix metalloproteinases (MMPs) is a potential strategy for osteoarthritis (OA) therapy, although delivering this effect in a spatially and temporally localised fashion remains a challenge.

Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities

no code implementations • 5 Jan 2021 • Heather E. Owston, Katrina M. Moisley, Giuseppe Tronci, Stephen J. Russell, Peter V. Giannoudis, Elena Jones

Additional to the PL absorption and release capabilities needed for MSC attraction and growth, PCL3%-E also provided a favourable surface for the proliferation and alignment of periosteum- and bone marrow derived-MSCs, whilst possessing a barrier function to cell migration.

Management