Interpretable HER2 scoring by evaluating clinical Guidelines through a weakly supervised, constrained Deep Learning Approach

no code implementations • 17 Nov 2022 • Manh Dan Pham, Cyprien Tilmant, Stéphanie Petit, Isabelle Salmon, Saima Ben Hadj, Rutger H. J. Fick

The evaluation of the Human Epidermal growth factor Receptor-2 (HER2) expression is an important prognostic biomarker for breast cancer treatment selection.

Initial condition assessment for reaction-diffusion glioma growth models: A translational MRI/histology (in)validation study

no code implementations • 2 Feb 2021 • Corentin Martens, Laetitia Lebrun, Christine Decaestecker, Thomas Vandamme, Yves-Rémi Van Eycke, Antonin Rovai, Thierry Metens, Olivier Debeir, Serge Goldman, Isabelle Salmon, Gaetan Van Simaeys

Our results suggest that (i) the previously suggested exponential decrease of the tumor cell density with the distance to the tumor core is not unreasonable but (ii) the edema outlines may in general not correspond to a cell density iso-contour and (iii) the commonly adopted tumor cell density value at these outlines is likely overestimated.