Search Results for author: Jeffrey A. Ruffolo

Found 2 papers, 1 papers with code

Deciphering antibody affinity maturation with language models and weakly supervised learning

no code implementations14 Dec 2021 Jeffrey A. Ruffolo, Jeffrey J. Gray, Jeremias Sulam

Understanding the composition of an individual's immune repertoire can provide insights into this process and reveal potential therapeutic antibodies.

Language Modelling Multiple Instance Learning +1

Improved antibody structure prediction by deep learning of side chain conformations

1 code implementation bioRxiv 2021 Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

When compared to alternative rotamer repacking methods, which require an input backbone structure, DeepSCAb predicts side chain conformations competitively.

Drug Discovery

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