no code implementations • 14 Mar 2024 • Leonardo Di Bari, Matteo Bisardi, Sabrina Cotogno, Martin Weigt, Francesco Zamponi
Our model uncovers a highly collective nature of epistasis, gradually changing the fitness effect of mutations in a diverging sequence context, rather than acting via strong interactions between individual mutations.
no code implementations • 4 Jun 2021 • Matteo Bisardi, Juan Rodriguez-Rivas, Francesco Zamponi, Martin Weigt
During their evolution, proteins explore sequence space via an interplay between random mutations and phenotypic selection.
