Search Results for author: Paul D. W. Kirk

Found 6 papers, 4 papers with code

Bayesian outcome-guided multi-view mixture models with applications in molecular precision medicine

no code implementations1 Mar 2023 Paul D. W. Kirk, Filippo Pagani, Sylvia Richardson

Clustering is commonly performed as an initial analysis step for uncovering structure in 'omics datasets, e. g. to discover molecular subtypes of disease.

Clustering

Topological Approximate Bayesian Computation for Parameter Inference of an Angiogenesis Model

1 code implementation26 Aug 2021 Thomas Thorne, Paul D. W. Kirk, Heather A. Harrington

Here we focus on recent work using topological data analysis to study different regimes of parameter space for a well-studied model of angiogenesis.

Topological Data Analysis

Kernel learning approaches for summarising and combining posterior similarity matrices

1 code implementation27 Sep 2020 Alessandra Cabassi, Sylvia Richardson, Paul D. W. Kirk

Here we build upon the notion of the posterior similarity matrix (PSM) in order to suggest new approaches for summarising the output of MCMC algorithms for Bayesian clustering models.

Clustering Data Integration

Two-step penalised logistic regression for multi-omic data with an application to cardiometabolic syndrome

1 code implementation1 Aug 2020 Alessandra Cabassi, Denis Seyres, Mattia Frontini, Paul D. W. Kirk

Building classification models that predict a binary class label on the basis of high dimensional multi-omics datasets poses several challenges, due to the typically widely differing characteristics of the data layers in terms of number of predictors, type of data, and levels of noise.

regression Variable Selection

Multiple kernel learning for integrative consensus clustering of 'omic datasets

1 code implementation15 Apr 2019 Alessandra Cabassi, Paul D. W. Kirk

KLIC frames the challenge of combining clustering structures as a multiple kernel learning problem, in which different datasets each provide a weighted contribution to the final clustering.

Clustering

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