no code implementations • 1 Mar 2023 • Paul D. W. Kirk, Filippo Pagani, Sylvia Richardson
Clustering is commonly performed as an initial analysis step for uncovering structure in 'omics datasets, e. g. to discover molecular subtypes of disease.
no code implementations • 29 Jul 2022 • Yannis Chaumeny, Johan van der Molen Moris, Anthony C. Davison, Paul D. W. Kirk
We consider the Bayesian mixture of finite mixtures (MFMs) and Dirichlet process mixture (DPM) models for clustering.
1 code implementation • 26 Aug 2021 • Thomas Thorne, Paul D. W. Kirk, Heather A. Harrington
Here we focus on recent work using topological data analysis to study different regimes of parameter space for a well-studied model of angiogenesis.
1 code implementation • 27 Sep 2020 • Alessandra Cabassi, Sylvia Richardson, Paul D. W. Kirk
Here we build upon the notion of the posterior similarity matrix (PSM) in order to suggest new approaches for summarising the output of MCMC algorithms for Bayesian clustering models.
1 code implementation • 1 Aug 2020 • Alessandra Cabassi, Denis Seyres, Mattia Frontini, Paul D. W. Kirk
Building classification models that predict a binary class label on the basis of high dimensional multi-omics datasets poses several challenges, due to the typically widely differing characteristics of the data layers in terms of number of predictors, type of data, and levels of noise.
1 code implementation • 15 Apr 2019 • Alessandra Cabassi, Paul D. W. Kirk
KLIC frames the challenge of combining clustering structures as a multiple kernel learning problem, in which different datasets each provide a weighted contribution to the final clustering.