A genome-scale deep learning model to predict gene expression changes of genetic perturbations from multiplex biological networks

no code implementations • 5 Mar 2024 • Lingmin Zhan, Yuanyuan Zhang, Yingdong Wang, Aoyi Wang, Caiping Cheng, Jinzhong Zhao, Wuxia Zhang, Peng Lia, Jianxin Chen

TranscriptionNet can predict transcriptional profiles for all genes in existing biological networks and increases perturbational gene expression changes for each type of genetic perturbation from a few thousand to 26, 945 genes.