Entropic contribution to phenotype fitness

no code implementations • 11 Apr 2023 • Pablo Catalán, Juan Antonio García-Martín, Jacobo Aguirre, José A. Cuesta, Susanna Manrubia

All possible phenotypes are not equally accessible to evolving populations.

The simple emergence of complex molecular function

no code implementations • 25 May 2021 • Susanna Manrubia

At odds with a traditional view of molecular evolution that seeks a descent-with-modification relationship between functional sequences, new functions can emerge {\it de novo} with relative ease.

Fat Tails and Black Swans: Exact Results for Multiplicative Processes with Resets

no code implementations • 25 May 2021 • Damián H. Zanette, Susanna Manrubia

We consider a class of multiplicative processes which, added with stochastic reset events, give origin to stationary distributions with power-law tails -- ubiquitous in the statistics of social, economic, and ecological systems.

Individual risk-aversion responses tune epidemics to critical transmissibility ($R=1$)

no code implementations • 21 May 2021 • Susanna Manrubia, Damián H. Zanette

We conclude that uncoordinated changes in human behavior can, by themselves, explain major qualitative and quantitative features of the epidemic process, as the emergence of multiple waves and the tendency to remain around $R=1$ observed worldwide after the first few waves of COVID-19.

Predictability: Can the turning point and end of an expanding epidemic be precisely forecast?

1 code implementation • 19 Apr 2020 • Mario Castro, Saúl Ares, José A. Cuesta, Susanna Manrubia

The time at which the growth in the number of infected individuals halts and starts decreasing cannot be calculated with certainty before the turning point is actually attained; neither can the end of the epidemic after the turning point.

From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics

no code implementations • 2 Feb 2020 • Susanna Manrubia, José A. Cuesta, Jacobo Aguirre, Sebastian E. Ahnert, Lee Altenberg, Alejandro V. Cano, Pablo Catalán, Ramon Diaz-Uriarte, Santiago F. Elena, Juan Antonio García-Martín, Paulien Hogeweg, Bhavin S. Khatri, Joachim Krug, Ard A. Louis, Nora S. Martin, Joshua L. Payne, Matthew J. Tarnowski, Marcel Weiß

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution.

Limited role of spatial self-structuring in emergent trade-offs during pathogen evolution

1 code implementation • 23 Apr 2018 • Victor Buendía, Miguel A. Muñoz, Susanna Manrubia

Pathogen transmission and virulence are main evolutionary variables broadly assumed to be linked through trade-offs.

Populations and Evolution