Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

1 code implementation • Nature Communications 2020 • Jan Zrimec, Christoph S. Börlin, Filip Buric, Azam Sheikh Muhammad, Rhongzen Chen, Verena Siewers, Vilhelm Verendel, Jens Nielsen, Mats Töpel, Aleksej Zelezniak

Co-evolution across coding and non-coding regions suggests that it is not single motifs or regions, but the entire gene regulatory structure and specific combination of regulatory elements that define gene expression levels.