Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain

no code implementations • 8 Oct 2022 • Yoshinao Katsu, Xiaozhi Lin, Ruigeng Ji, Ze Chen, Yui Kamisaka, Koto Bamba, Michael E. Baker

Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line.

Specificity

Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain

no code implementations • 27 Jun 2021 • Yoshinao Katsu, Shin Oana, Xiaozhi Lin, Susumu Hyodo, Michael E. Baker

Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates.

Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec

no code implementations • 24 Jan 2021 • Xiaozhi Lin, Wataru Takagi, Susumu Hyodo, Shigeho Ijiri, Yoshinao Katsu, Michael E. Baker

At 1 nM steroid, human PR is activated only by progesterone and11-deoxycorticosterone indicating increased specificity for progestins and corticosteroids during the evolution of human PR.

Specificity