Network-based coverage of mutational profiles reveals cancer genes

26 Apr 2017Borislav H. HristovMona Singh

A central goal in cancer genomics is to identify the somatic alterations that underpin tumor initiation and progression. This task is challenging as the mutational profiles of cancer genomes exhibit vast heterogeneity, with many alterations observed within each individual, few shared somatically mutated genes across individuals, and important roles in cancer for both frequently and infrequently mutated genes... (read more)

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