no code implementations • 17 Jan 2020 • Borislav H. Hristov, Bernard Chazelle, Mona Singh
Overall, our work suggests that guided network propagation approaches that utilize both prior and new data are a powerful means to identify disease genes.
no code implementations • 26 Apr 2017 • Borislav H. Hristov, Mona Singh
Here, we introduce a method that considers per-individual mutational profiles within the context of protein-protein interaction networks in order to identify small connected subnetworks of genes that, while not individually frequently mutated, comprise pathways that are perturbed across (i. e., "cover") a large fraction of the individuals.
