The evolution and structure of biomedical knowledge on cytochrome P450

27 Nov 2017  ·  David Fajardo-Ortiz, Miguel Lara, Victor M. Castano ·

Cytochrome P450 are fundamental proteins to the metabolism of drugs and other relevant processes. through a combination of text mining and network analysis of the P450 literature we mapped the emergence and evolution of the biomedical research communities working on this family of proteins... Our results suggest that the historical research communities that worked on P450 emerged and were organized mainly around methodological achievements like the induction of animal liver microsomal P450 by drugs, the use of chemical inhibitors of P450 enzymes in in-vitro metabolism studies and the development of E. coli expression systems. We found clear evidence that P450 research indeed constitutes a material scientific culture, as we discuss in the text. read more

PDF Abstract
No code implementations yet. Submit your code now

Tasks


Datasets


  Add Datasets introduced or used in this paper

Results from the Paper


  Submit results from this paper to get state-of-the-art GitHub badges and help the community compare results to other papers.

Methods


No methods listed for this paper. Add relevant methods here