Sex Differences in 6-Year Progression of White Matter Hyperintensities in Non-Demented Older Adults: Sydney Memory and Ageing Study

no code implementations • 17 Jul 2023 • Abdullah Alqarni, Wei Wen, Ben C. P. Lam, Nicole Kochan, Henry Brodaty, Perminder S. Sachdev, Jiyang Jiang

Conclusion: The findings highlighted sex differences in the associations between WMH progression and cognition decline over time, suggesting sex-specific strategies in managing WMH accumulations in ageing.

Hormonal Factors Moderate the Associations Between Vascular Risk Factors and White Matter Hyperintensities

no code implementations • 12 May 2022 • Abdullah Alqarni, Wei Wen, Ben C. P. Lam, John D. Crawford, Perminder S. Sachdev, Jiyang Jiang

Generalised linear models were applied to examine 1) the main effects of vascular (body mass index, hip to waist ratio, pulse wave velocity, hypercholesterolemia, diabetes, hypertension, smoking status) and hormonal (testosterone levels, contraceptive pill, hormone replacement therapy, menopause) factors on WMH, and 2) the moderation effects of hormonal factors on the relationship between vascular risk factors and WMH volumes.

Management