no code implementations • 16 Apr 2024 • Albert Powers, Philip Angelos, Alexandria Bond, Emily Farina, Carolyn Fredericks, Jay Gandhi, Maximillian Greenwald, Gabriela Hernandez-Busot, Gabriel Hosein, Megan Kelley, Catalina Mourgues, William Palmer, Julia Rodriguez-Sanchez, Rashina Seabury, Silmilly Toribio, Raina Vin, Jeremy Weleff, David Benrimoh
We propose a model for understanding the emergence of psychotic symptoms within the context of an adaptive, developing neural system.
no code implementations • 20 Feb 2024 • Catalina Mourgues-Codern, David Benrimoh, Jay Gandhi, Emily A. Farina, Raina Vin, Tihare Zamorano, Deven Parekh, Ashok Malla, Ridha Joober, Martin Lepage, Srividya N. Iyer, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara Cornblatt, Matcheri Keshavan, William S. Stone, Daniel H. Mathalon, Diana O. Perkins, Elaine F. Walker, Tyrone D. Cannon, Scott W. Woods, Jai L. Shah, Albert R. Powers
In all three samples, participants were more likely to report the onset of delusion-spectrum symptoms prior to hallucination-spectrum symptoms (odds ratios (OR): NAPLS 2 = 4. 09; NAPLS 3 = 4. 14; PEPP, Z = 7. 01, P < 0. 001) and to present with only delusions compared to only hallucinations (OR: NAPLS 2 = 5. 6; NAPLS 3 = 11. 11; PEPP = 42. 75).
no code implementations • 24 Jun 2023 • David Benrimoh, Victoria L. Fisher, Rashina Seabury, Ely Sibarium, Catalina Mourgues, Doris Chen, Albert Powers
Replicating past results, higher CH rates were associated with measures of higher hallucination-proneness and recent hallucinatory experiences; CH rates were positively correlated with increased prior weighting; and increased prior weighting was related to recent hallucinatory experiences.
no code implementations • 24 Mar 2023 • David Benrimoh, Akiva Kleinerman, Toshi A. Furukawa, Charles F. Reynolds III, Eric Lenze, Jordan Karp, Benoit Mulsant, Caitrin Armstrong, Joseph Mehltretter, Robert Fratila, Kelly Perlman, Sonia Israel, Myriam Tanguay-Sela, Christina Popescu, Grace Golden, Sabrina Qassim, Alexandra Anacleto, Adam Kapelner, Ariel Rosenfeld, Gustavo Turecki
We analyzed data from six clinical trials of pharmacological treatment for depression (total n = 5438) using the Differential Prototypes Neural Network (DPNN), a neural network model that derives patient prototypes which can be used to derive treatment-relevant patient clusters while learning to generate probabilities for differential treatment response.
no code implementations • 6 Mar 2023 • Grace Golden, Christina Popescu, Sonia Israel, Kelly Perlman, Caitrin Armstrong, Robert Fratila, Myriam Tanguay-Sela, David Benrimoh
Clinical decision support systems (CDSS) augmented with artificial intelligence (AI) models are emerging as potentially valuable tools in healthcare.
no code implementations • 9 Dec 2022 • David Benrimoh, Victoria Fisher, Catalina Mourgues, Andrew D. Sheldon, Ryan Smith, Albert R. Powers
Computational psychiatry is a field aimed at developing formal models of information processing in the human brain, and how alterations in this processing can lead to clinical phenomena.
no code implementations • 25 Mar 2021 • David Benrimoh, Ely Sibarium, Andrew Sheldon, Albert Powers
We discuss how computational models explain the resulting reduction in symptoms, as well as the predictions these models make about potential responses of patients to modifications or to different variations of these interventions.
no code implementations • 12 Mar 2019 • Ariel Rosenfeld, David Benrimoh, Caitrin Armstrong, Nykan Mirchi, Timothe Langlois-Therrien, Colleen Rollins, Myriam Tanguay-Sela, Joseph Mehltretter, Robert Fratila, Sonia Israel, Emily Snook, Kelly Perlman, Akiva Kleinerman, Bechara Saab, Mark Thoburn, Cheryl Gabbay, Amit Yaniv-Rosenfeld
Mental health conditions cause a great deal of distress or impairment; depression alone will affect 11% of the world's population.