no code implementations • 24 Mar 2023 • David Benrimoh, Akiva Kleinerman, Toshi A. Furukawa, Charles F. Reynolds III, Eric Lenze, Jordan Karp, Benoit Mulsant, Caitrin Armstrong, Joseph Mehltretter, Robert Fratila, Kelly Perlman, Sonia Israel, Myriam Tanguay-Sela, Christina Popescu, Grace Golden, Sabrina Qassim, Alexandra Anacleto, Adam Kapelner, Ariel Rosenfeld, Gustavo Turecki
We analyzed data from six clinical trials of pharmacological treatment for depression (total n = 5438) using the Differential Prototypes Neural Network (DPNN), a neural network model that derives patient prototypes which can be used to derive treatment-relevant patient clusters while learning to generate probabilities for differential treatment response.