Predicting Splicing from Primary Sequence with Deep Learning

4 code implementations • A Cell Press journal 2019 • Kishore Jaganathan, Sofia Kyriazopoulou Panagiotopoulou, Jeremy F. McRae, Siavash Fazel Darbandi, David Knowles, Yang I. Li, Jack A. Kosmicki, Juan Arbelaez, Wenwu Cui, Grace B. Schwartz, Eric D. Chow, Efstathios Kanterakis, Hong Gao, Amirali Kia, Serafim Batzoglou, Stephan J. Sanders, Kyle Kai-How Farh

The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the mechanisms by which the cellular machinery achieves such specificity are incompletely understood.

Specificity

A Birth-Death Process for Feature Allocation

no code implementations • ICML 2017 • Konstantina Palla, David Knowles, Zoubin Ghahramani

We propose a Bayesian nonparametric prior over feature allocations for sequential data, the birth-death feature allocation process (BDFP).