no code implementations • 23 Aug 2022 • Jialong Jiang, Sisi Chen, Tiffany Tsou, Christopher S. McGinnis, Tahmineh Khazaei, Qin Zhu, Jong H. Park, Paul Rivaud, Inna-Marie Strazhnik, Eric D. Chow, David A. Sivak, Zev J. Gartner, Matt Thomson
We develop a unified mathematical model that quantitatively describes the transcriptome scale response of myeloid and lymphoid cell types to individual drugs and drug combinations through a single inferred regulatory network.
4 code implementations • A Cell Press journal 2019 • Kishore Jaganathan, Sofia Kyriazopoulou Panagiotopoulou, Jeremy F. McRae, Siavash Fazel Darbandi, David Knowles, Yang I. Li, Jack A. Kosmicki, Juan Arbelaez, Wenwu Cui, Grace B. Schwartz, Eric D. Chow, Efstathios Kanterakis, Hong Gao, Amirali Kia, Serafim Batzoglou, Stephan J. Sanders, Kyle Kai-How Farh
The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the mechanisms by which the cellular machinery achieves such specificity are incompletely understood.