Modelling Technical and Biological Effects in scRNA-seq data with Scalable GPLVMs

1 code implementation • 14 Sep 2022 • Vidhi Lalchand, Aditya Ravuri, Emma Dann, Natsuhiko Kumasaka, Dinithi Sumanaweera, Rik G. H. Lindeboom, Shaista Madad, Sarah A. Teichmann, Neil D. Lawrence

Single-cell RNA-seq datasets are growing in size and complexity, enabling the study of cellular composition changes in various biological/clinical contexts.

Data Integration Dimensionality Reduction +1

Bridging the Gaps in Statistical Models of Protein Alignment

no code implementations • 2 Oct 2020 • Dinithi Sumanaweera, Lloyd Allison, Arun S. Konagurthu

This work demonstrates how a complete statistical model quantifying the evolution of pairs of aligned proteins can be constructed from a time-parameterised substitution matrix and a time-parameterised 3-state alignment machine.