1 code implementation • 25 Oct 2021 • Konstantinos Giannakis, Joanna M. Chustecki, Iain G. Johnston
Here, we asked whether mitochondrial dynamics may allow individual mitochondria to `collect' a full copy of the mtDNA genome over time, by facilitating exchange between individuals.
no code implementations • 24 Feb 2020 • Iain G. Johnston
Each round, a limited resource (`luck') may be spent on a gamble to amplify the benefit from a win or mitigate the deficit from a loss.
no code implementations • 13 Dec 2019 • Ryan Kerr, Sara Jabbari, Iain G. Johnston
Here, we consider the energy dependence of a highly generalisable decision-making regulatory network, and show that energy variability changes the sets of decisions a cell can make and the ease with which they can be made.
2 code implementations • 28 Nov 2019 • Sam F. Greenbury, Mauricio Barahona, Iain G. Johnston
The explosion of data throughout the biomedical sciences provides unprecedented opportunities to learn about the dynamics of evolution and disease progression, but harnessing these large and diverse datasets remains challenging.
Quantitative Methods Genomics Methodology
1 code implementation • 6 Sep 2018 • Juvid Aryaman, Charlotte Bowles, Nick S. Jones, Iain G. Johnston
The role of the resulting mitochondrial networks in the time evolution of the cellular proportion of mutated mtDNA molecules (heteroplasmy), and cell-to-cell variability in heteroplasmy (heteroplasmy variance), remains incompletely understood.
no code implementations • 6 Sep 2018 • Juvid Aryaman, Iain G. Johnston, Nick S. Jones
The diverse sources of mitochondrial heterogeneity, as well as their increasingly recognised role in contributing to cellular heterogeneity, highlights the need for future single-cell mitochondrial measurements in the context of cellular noise studies.
1 code implementation • 10 Oct 2009 • Iain G. Johnston, Ard A. Louis, Jonathan P. K. Doye
We use computer simulations to study a model, first proposed by Wales [1], for the reversible and monodisperse self-assembly of simple icosahedral virus capsid structures.
Biomolecules