no code implementations • 20 Dec 2021 • Nils R. Winter, Ramona Leenings, Jan Ernsting, Kelvin Sarink, Lukas Fisch, Daniel Emden, Julian Blanke, Janik Goltermann, Nils Opel, Carlotta Barkhau, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marco Mauritz, Marius Gruber, Elisabeth J. Leehr, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Igor Nenadic, Markus Nöthen, Andreas Forstner, Marcella Rietschel, Joachim Groß, Jochen Bauer, Walter Heindel, Till Andlauer, Simon Eickhoff, Tilo Kircher, Udo Dannlowski, Tim Hahn
Discussion: We provide a large-scale, multimodal analysis of univariate biological differences between MDD patients and controls and show that even under near-ideal conditions and for maximum biological differences, deviations are extremely small and similarity dominates.
no code implementations • 21 Jul 2021 • Tim Hahn, Hamidreza Jamalabadi, Daniel Emden, Janik Goltermann, Jan Ernsting, Nils R. Winter, Lukas Fisch, Ramona Leenings, Kelvin Sarink, Vincent Holstein, Marius Gruber, Dominik Grotegerd, Susanne Meinert, Katharina Dohm, Elisabeth J. Leehr, Maike Richter, Lisa Sindermann, Verena Enneking, Hannah Lemke, Stephanie Witt, Marcella Rietschel, Katharina Brosch, Julia-Katharina Pfarr, Tina Meller, Kai Gustav Ringwald, Simon Schmitt, Frederike Stein, Igor Nenadic, Tilo Kircher, Bertram Müller-Myhsok, Till F. M. Andlauer, Jonathan Repple, Udo Dannlowski, Nils Opel
We quantified the theoretical energy required for each patient and time-point to reach a symptom-free state given individual symptom-network topology (E 0 ) and 1) tested if E 0 predicts future symptom improvement and 2) whether this relationship is moderated by Polygenic Risk Scores (PRS) of mental disorders, childhood maltreatment experience, and self-reported resilience.
no code implementations • 21 Jul 2021 • Tim Hahn, Nils R. Winter, Jan Ernsting, Marius Gruber, Marco J. Mauritz, Lukas Fisch, Ramona Leenings, Kelvin Sarink, Julian Blanke, Vincent Holstein, Daniel Emden, Marie Beisemann, Nils Opel, Dominik Grotegerd, Susanne Meinert, Walter Heindel, Stephanie Witt, Marcella Rietschel, Markus M. Nöthen, Andreas J. Forstner, Tilo Kircher, Igor Nenadic, Andreas Jansen, Bertram Müller-Myhsok, Till F. M. Andlauer, Martin Walter, Martijn P. van den Heuvel, Hamidreza Jamalabadi, Udo Dannlowski, Jonathan Repple
Conclusions: We show that network controllability is related to genetic, individual, and familial risk in MDD patients.
no code implementations • 13 Dec 2019 • Claas Flint, Micah Cearns, Nils Opel, Ronny Redlich, David M. A. Mehler, Daniel Emden, Nils R. Winter, Ramona Leenings, Simon B. Eickhoff, Tilo Kircher, Axel Krug, Igor Nenadic, Volker Arolt, Scott Clark, Bernhard T. Baune, Xiaoyi Jiang, Udo Dannlowski, Tim Hahn
We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of more data, larger machine learning studies consistently show much weaker performance than the numerous small-scale studies.
1 code implementation • 24 Nov 2019 • Claas Flint, Katharina Förster, Sophie A. Koser, Carsten Konrad, Pienie Zwitserlood, Klaus Berger, Marco Hermesdorf, Tilo Kircher, Igor Nenadic, Axel Krug, Bernhard T. Baune, Katharina Dohm, Ronny Redlich, Nils Opel, Volker Arolt, Tim Hahn, Xiaoyi Jiang, Udo Dannlowski, Dominik Grotegerd
Subsequently, the classifier was applied to $N = 26$ TWs.