1 code implementation • 30 Oct 2023 • Thomas Williams, James M. McCaw, James Osborne
The role of direct cell-to-cell spread in viral infections - where virions spread between host and susceptible cells without needing to be secreted into the extracellular environment - has come to be understood as essential to the dynamics of medically significant viruses like hepatitis C and influenza.
no code implementations • 1 Aug 2022 • Thomas Williams, James McCaw, James Osborne
There has been an increasing recognition of the utility of models of the spatial dynamics of viral spread within tissues.
1 code implementation • 19 Jul 2021 • Claire Miller, Edmund Crampin, James Osborne
In this paper we will investigate combining a (mass action) subcellular model of desquamation with a three dimensional (cell centre based) multicellular model of the interfollicular epidermis to better understand maintenance of epidermal thickness.
2 code implementations • 27 Nov 2018 • Claire Miller, Edmund Crampin, James Osborne
Using an established model of the inter-follicular epidermis we find there is a limit to the proliferative cell densities that can be maintained in the basal layer (the niche) if we do not include additional mechanisms to stop the loss of proliferative cells from the niche.
