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Found 8 papers, 1 papers with code
Spatial information allows inference of the prevalence of direct cell-to-cell viral infection
The role of direct cell-to-cell spread in viral infections - where virions spread between host and susceptible cells without needing to be secreted into the extracellular environment - has come to be understood as essential to the dynamics of medically significant viruses like hepatitis C and influenza.
Mathematical models of Plasmodium vivax transmission: a scoping review
In this article, we provide a scoping review of mathematical models that capture P. vivax transmission dynamics published between January 1988 and May 2023 to provide a comprehensive summary of the mathematical models and techniques used to model P. vivax dynamics.
Superinfection and the hypnozoite reservoir for Plasmodium vivax: a general framework
Superinfection, which is driven by temporally proximate mosquito inoculation and/or hypnozoite activation events, is an important feature of P. vivax.
Optimal interruption of P. vivax malaria transmission using mass drug administration
Treatment with a radical cure to target the hypnozoite reservoir is a potential tool to control or eliminate \textit{P. vivax}.
A hybrid transmission model for Plasmodium vivax accounting for superinfection, immunity and the hypnozoite reservoir
To model transmission-blocking and antidisease immunity, we allow for geometric decay in the respective probabilities of successful human-to-mosquito transmission and symptomatic blood-stage infection as a function of this immunity level.
A model for malaria treatment evaluation in the presence of multiple species
We apply this model to assess the implications of different treatment coverage of radical cure for mixed and P. vivax infections and a so-called "unified radical cure" treatment strategy for P. falciparum, P. vivax and mixed infections.
Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure
By constructing an open network of infinite server queues, we derive analytic expressions for several quantities of epidemiological significance, including the size of the hypnozoite reservoir; the relative contribution of relapses to the infection burden; the distribution of multiple infections; the cumulative number of recurrences over time, and the time to first recurrence following drug treatment.
An activation-clearance model for Plasmodium vivax malaria
We then extend our analysis to consider activation-clearance dynamics for a single mosquito bite, which can simultaneously establish multiple hypnozoites, under the assumption of independent hypnozoite behaviour.
