no code implementations • 30 Aug 2023 • Samantha M. Webster, Mira B. May, Barrett M. Powell, Joseph H. Davis
Throughout the history of electron microscopy, ribosomes have served as an ideal subject for imaging and technological development, which in turn has driven our understanding of ribosomal biology.
no code implementations • 3 Jul 2021 • Ellen D. Zhong, Adam Lerer, Joseph H. Davis, Bonnie Berger
Although reconstruction algorithms typically model the 3D volume as a generic function parameterized as a voxel array or neural network, the underlying atomic structure of the protein of interest places well-defined physical constraints on the reconstructed structure.
no code implementations • ICCV 2021 • Ellen D. Zhong, Adam Lerer, Joseph H. Davis, Bonnie Berger
In this work we describe cryoDRGN2, an ab initio reconstruction algorithm, which can jointly estimate image poses and learn a neural model of a distribution of 3D structures on real heterogeneous cryo-EM data.
2 code implementations • ICLR 2020 • Ellen D. Zhong, Tristan Bepler, Joseph H. Davis, Bonnie Berger
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution.