no code implementations • 26 May 2022 • Qi Li, Khalique Newaz, Tijana Milenković
Here, we evaluate whether analyzing a weighted dynamic aging-specific subnetwork inferred from newer GE and PPIN data improves prediction accuracy upon analyzing the best current subnetwork inferred from outdated data.
no code implementations • 14 May 2021 • Khalique Newaz, Jacob Piland, Patricia L. Clark, Scott J. Emrich, Jun Li, Tijana Milenkovic
Here, we propose for the first time a way to model 3D structures of proteins as dynamic PSNs, with the hypothesis that this will improve upon the current state-of-the-art PSC approaches that are based on static PSNs (and thus upon the existing state-of-the-art sequence and other 3D structural approaches).
no code implementations • 7 May 2020 • Qi Li, Khalique Newaz, Tijana Milenković
Instead, we recently inferred a dynamic aging-specific subnetwork using a methodologically more advanced notion of network propagation (NP), which improved upon Induced dynamic aging-specific subnetwork in a different task, that of unsupervised analyses of the aging process.
no code implementations • 7 Oct 2019 • Hongyu Guo, Khalique Newaz, Scott Emrich, Tijana Milenkovic, Jun Li
We develop a weighted network that depicts the protein structures, and more importantly, we propose the first graphlet-based measure that applies to weighted networks.
no code implementations • 15 Jul 2018 • Khalique Newaz, Tijana Milenkovic
We use prominent existing NP methods in a new task of inferring a dynamic rather than static condition-specific (aging-related) subnetwork.
1 code implementation • 12 Apr 2018 • Khalique Newaz, Mahboobeh Ghalehnovi, Arash Rahnama, Panos J. Antsaklis, Tijana Milenkovic
Experimental determination of protein function is resource-consuming.