Search Results for author: Michael P. H. Stumpf

Found 11 papers, 4 papers with code

Hypergraph Animals

no code implementations3 Apr 2023 Michael P. H. Stumpf

Together these two findings imply that we need to spend more effort on investigating and developing suitable conditional ensembles of random hypergraph that can capture real-world structures and their complex dependency structures.

Open Problems in Mathematical Biology

no code implementations20 Jun 2022 Sean T. Vittadello, Michael P. H. Stumpf

Biology is data-rich, and it is equally rich in concepts and hypotheses.

A group theoretic approach to model comparison with simplicial representations

no code implementations3 Nov 2021 Sean T. Vittadello, Michael P. H. Stumpf

First, we present a rigorous and automatable methodology for the core process of comparison by equivalence, namely determining the vertices in a simplicial representation, corresponding to model components, that are conceptually related and the identification of these vertices via simplicial operations.

Julia for Biologists

1 code implementation21 Sep 2021 Elisabeth Roesch, Joe G. Greener, Adam L. MacLean, Huda Nassar, Christopher Rackauckas, Timothy E. Holy, Michael P. H. Stumpf

Increasing emphasis on data and quantitative methods in the biomedical sciences is making biological research more computational.

Bayesian and Algebraic Strategies to Design in Synthetic Biology

no code implementations17 Aug 2021 Robyn P. Araujo, Sean T. Vittadello, Michael P. H. Stumpf

Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity.

Model comparison via simplicial complexes and persistent homology

1 code implementation24 Dec 2020 Sean T. Vittadello, Michael P. H. Stumpf

In many scientific and technological contexts we have only a poor understanding of the structure and details of appropriate mathematical models.

Model Selection Algebraic Topology Quantitative Methods

Non-equilibrium statistical physics, transitory epigenetic landscapes, and cell fate decision dynamics

no code implementations9 Nov 2020 Anissa Guillemin, Michael P. H. Stumpf

Statistical physics provides a useful perspective for the analysis of many complex systems; it allows us to relate microscopic fluctuations to macroscopic observations.

Decision Making

Construction of quasi-potentials for stochastic dynamical systems: an optimization approach

1 code implementation18 May 2018 Rowan D Brackston, Andrew Wynn, Michael P. H. Stumpf

The construction of effective and informative landscapes for stochastic dynamical systems has proven a long-standing and complex problem.

Optimization and Control Dynamical Systems Quantitative Methods

On optimality of kernels for approximate Bayesian computation using sequential Monte Carlo

no code implementations30 Jun 2011 Sarah Filippi, Chris Barnes, Julien Cornebise, Michael P. H. Stumpf

Here we discuss how to construct the perturbation kernels that are required in ABC SMC approaches, in order to construct a set of distributions that start out from a suitably defined prior and converge towards the unknown posterior.

Computation

Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems

no code implementations14 Jan 2009 Tina Toni, David Welch, Natalja Strelkowa, Andreas Ipsen, Michael P. H. Stumpf

Approximate Bayesian computation methods can be used to evaluate posterior distributions without having to calculate likelihoods.

Computation Methodology

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