no code implementations • 3 Apr 2023 • Michael P. H. Stumpf
Together these two findings imply that we need to spend more effort on investigating and developing suitable conditional ensembles of random hypergraph that can capture real-world structures and their complex dependency structures.
no code implementations • 20 Jun 2022 • Sean T. Vittadello, Michael P. H. Stumpf
Biology is data-rich, and it is equally rich in concepts and hypotheses.
no code implementations • 3 Nov 2021 • Sean T. Vittadello, Michael P. H. Stumpf
First, we present a rigorous and automatable methodology for the core process of comparison by equivalence, namely determining the vertices in a simplicial representation, corresponding to model components, that are conceptually related and the identification of these vertices via simplicial operations.
1 code implementation • 21 Sep 2021 • Elisabeth Roesch, Joe G. Greener, Adam L. MacLean, Huda Nassar, Christopher Rackauckas, Timothy E. Holy, Michael P. H. Stumpf
Increasing emphasis on data and quantitative methods in the biomedical sciences is making biological research more computational.
no code implementations • 17 Aug 2021 • Robyn P. Araujo, Sean T. Vittadello, Michael P. H. Stumpf
Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity.
1 code implementation • 24 Dec 2020 • Sean T. Vittadello, Michael P. H. Stumpf
In many scientific and technological contexts we have only a poor understanding of the structure and details of appropriate mathematical models.
Model Selection Algebraic Topology Quantitative Methods
no code implementations • 9 Nov 2020 • Anissa Guillemin, Michael P. H. Stumpf
Statistical physics provides a useful perspective for the analysis of many complex systems; it allows us to relate microscopic fluctuations to macroscopic observations.
1 code implementation • PNAS 2020 • Michael P. H. Stumpf, Carsten Wiuf, Robert M. May
Most studies of networks have only looked at small subsets of the true network.
1 code implementation • 18 May 2018 • Rowan D Brackston, Andrew Wynn, Michael P. H. Stumpf
The construction of effective and informative landscapes for stochastic dynamical systems has proven a long-standing and complex problem.
Optimization and Control Dynamical Systems Quantitative Methods
no code implementations • 30 Jun 2011 • Sarah Filippi, Chris Barnes, Julien Cornebise, Michael P. H. Stumpf
Here we discuss how to construct the perturbation kernels that are required in ABC SMC approaches, in order to construct a set of distributions that start out from a suitably defined prior and converge towards the unknown posterior.
Computation
no code implementations • 14 Jan 2009 • Tina Toni, David Welch, Natalja Strelkowa, Andreas Ipsen, Michael P. H. Stumpf
Approximate Bayesian computation methods can be used to evaluate posterior distributions without having to calculate likelihoods.
Computation Methodology