no code implementations • 19 Dec 2022 • Marc Courchesne, Colin Wakefield, Karen Nygard, Patrick Burns, Gilles Fecteau, Andre Desrochers, Mingju Cao, Martin G. Frasch
The efferent and afferent effects of the vagus nerve on the developing brain have remained enigmatic.
no code implementations • 27 Mar 2022 • Mingju Cao, Shikha Kuthiala, Keven Jason Jean, Hai Lun Liu, Marc Courchesne, Karen Nygard, Patrick Burns, André Desrochers, Gilles Fecteau, Christophe Faure, Martin G. Frasch
Under conditions of moderate fetal inflammation, this is related to higher levels of gut inflammation; the efferent VNS reduces the systemic inflammatory response as well as restores both the levels of glucose and terminal ileum inflammation, but not the insulin levels.
no code implementations • 19 Aug 2020 • Aude Castel, Patrick M. Burns, Javier Benito, Hai L. Liu, Shikha Kuthiala, Lucien D. Durosier, Yael S. Frank, Mingju Cao, Marilène Paquet, Gilles Fecteau, André Desrochers, Martin G. Frasch
Conclusions: This study describes a new surgical procedure allowing to record and manipulate chronically the vagus nerve activity in an animal model of human pregnancy.
no code implementations • 10 Feb 2020 • Aude Castel, Patrick Burns, Colin Wakefield, Keven. J. Jean, Yael S. Frank, Mingju Cao, Andre Desrochers, Gilles Fecteau, Christophe Faure, Christophe L. Herry, Martin G. Frasch
We evaluated the effect of vagus nerve stimulation (VNS) on vagus nerve electroneurogram (VENG) and the systemic inflammatory response induced by a high dose of LPS in neonatal piglets to mimic late-onset neonatal sepsis.