SARS-CoV-2 Wastewater Genomic Surveillance: Approaches, Challenges, and Opportunities

no code implementations • 23 Sep 2023 • Viorel Munteanu, Michael Saldana, Dumitru Ciorba, Viorel Bostan, Justin Maine Su, Nadiia Kasianchuk, Nitesh Kumar Sharma, Sergey Knyazev, Victor Gordeev, Eva Aßmann, Andrei Lobiuc, Mihai Covasa, Keith A. Crandall, Wenhao O. Ouyang, Nicholas C. Wu, Christopher Mason, Braden T Tierney, Alexander G Lucaci, Alex Zelikovsky, Fatemeh Mohebbi, Pavel Skums, Cynthia Gibas, Jessica Schlueter, Piotr Rzymski, Helena Solo-Gabriele, Martin Hölzer, Adam Smith, Serghei Mangul

The existing bioinformatics tools used to analyze wastewater sequencing data are often based on previously developed methods for quantifying the expression of transcripts or viral diversity.

A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

1 code implementation • Immunity 2022 • Yiquan Wang, Meng Yuan, Huibin Lv, Jian Peng, Ian A. Wilson, Nicholas C. Wu

Global research to combat the COVID-19 pandemic has led to the isolation and characterization of thousands of human antibodies to the SARS-CoV-2 spike protein, providing an unprecedented opportunity to study the antibody response to a single antigen.

Antibody-antigen binding prediction

Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity

1 code implementation • 14 Jul 2020 • Zachary Montague, Huibin Lv, Jakub Otwinowski, William S. DeWitt, Giulio Isacchini, Garrick K. Yip, Wilson W. Ng, Owen Tak-Yin Tsang, Meng Yuan, Hejun Liu, Ian A. Wilson, J. S. Malik Peiris, Nicholas C. Wu, Armita Nourmohammad, Chris Ka Pun Mok

Using single-cell sequencing, we verified reactivity of BCRs shared among individuals to SARS-CoV-2 epitopes.