COVID-Datathon: Biomarker identification for COVID-19 severity based on BALF scRNA-seq data

1 code implementation • 11 Oct 2021 • Seyednami Niyakan, Xiaoning Qian

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence began in late 2019 and has since spread rapidly worldwide.

SimCD: Simultaneous Clustering and Differential expression analysis for single-cell transcriptomic data

1 code implementation • 4 Apr 2021 • Seyednami Niyakan, Ehsan Hajiramezanali, Shahin Boluki, Siamak Zamani Dadaneh, Xiaoning Qian

We develop a new method -- SimCD -- that explicitly models cell heterogeneity and dynamic differential changes in one unified hierarchical gamma-negative binomial (hGNB) model, allowing simultaneous cell clustering and differential expression analysis for scRNA-seq data.

Clustering