Search Results for author: Yann Le Guen

Found 2 papers, 1 papers with code

Improving genetic risk prediction across diverse population by disentangling ancestry representations

no code implementations10 May 2022 Prashnna K Gyawali, Yann Le Guen, Xiaoxia Liu, Hua Tang, James Zou, Zihuai He

This can lead to biases in the risk predictors resulting in poor generalization when applied to minority populations and admixed individuals such as African Americans.

Genetic Risk Prediction

Deep neural networks with controlled variable selection for the identification of putative causal genetic variants

1 code implementation29 Sep 2021 Peyman H. Kassani, Fred Lu, Yann Le Guen, Zihuai He

The merit of the proposed method includes: (1) flexible modelling of the non-linear effect of genetic variants to improve statistical power; (2) multiple knockoffs in the input layer to rigorously control false discovery rate; (3) hierarchical layers to substantially reduce the number of weight parameters and activations to improve computational efficiency; (4) de-randomized feature selection to stabilize identified signals.

Computational Efficiency feature selection +1

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