no code implementations • 10 May 2022 • Prashnna K Gyawali, Yann Le Guen, Xiaoxia Liu, Hua Tang, James Zou, Zihuai He
This can lead to biases in the risk predictors resulting in poor generalization when applied to minority populations and admixed individuals such as African Americans.
1 code implementation • 29 Sep 2021 • Peyman H. Kassani, Fred Lu, Yann Le Guen, Zihuai He
The merit of the proposed method includes: (1) flexible modelling of the non-linear effect of genetic variants to improve statistical power; (2) multiple knockoffs in the input layer to rigorously control false discovery rate; (3) hierarchical layers to substantially reduce the number of weight parameters and activations to improve computational efficiency; (4) de-randomized feature selection to stabilize identified signals.