How Many Annotators Do We Need? -- A Study on the Influence of Inter-Observer Variability on the Reliability of Automatic Mitotic Figure Assessment

no code implementations • 4 Dec 2020 • Frauke Wilm, Christof A. Bertram, Christian Marzahl, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Kathrin Becker, Mark Bennett, Sarah Corner, Brieuc Cossic, Daniela Denk, Martina Dettwiler, Beatriz Garcia Gonzalez, Corinne Gurtner, Annika Lehmbecker, Sophie Merz, Stephanie Plog, Anja Schmidt, Rebecca C. Smedley, Marco Tecilla, Tuddow Thaiwong, Katharina Breininger, Matti Kiupel, Andreas Maier, Robert Klopfleisch, Marc Aubreville

Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours.

$H^1$-Stability of the $L^2$-Projection onto Finite Element Spaces on Adaptively Refined Quadrilateral Meshes

1 code implementation • 28 Aug 2020 • Mazen Ali, Stefan A. Funken, Anja Schmidt

The $L^2$-orthogonal projection $\Pi_h:L^2(\Omega)\rightarrow\mathbb{V}_h$ onto a finite element (FE) space $\mathbb{V}_h$ is called $H^1$-stable iff $\|\nabla\Pi_h u\|_{L^2(\Omega)}\leq C\|u\|_{H^1(\Omega)}$, for any $u\in H^1(\Omega)$ with a positive constant $C\neq C(h)$ independent of the mesh size $h>0$.

Numerical Analysis Numerical Analysis 65M50

Deep learning algorithms out-perform veterinary pathologists in detecting the mitotically most active tumor region

1 code implementation • 12 Feb 2019 • Marc Aubreville, Christof A. Bertram, Christian Marzahl, Corinne Gurtner, Martina Dettwiler, Anja Schmidt, Florian Bartenschlager, Sophie Merz, Marco Fragoso, Olivia Kershaw, Robert Klopfleisch, Andreas Maier

Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes.

object-detection Object Detection +1