Search Results for author: David A. Sivak

Found 4 papers, 2 papers with code

Signal in the noise: temporal variation in exponentially growing populations

1 code implementation22 Apr 2023 Eric W. Jones, Joshua Derrick, Roger M. Nisbet, Will Ludington, David A. Sivak

In exponential population growth, variability in the timing of individual division events and environmental factors (including stochastic inoculation) compound to produce variable growth trajectories.

Therapeutic algebra of immunomodulatory drug responses at single-cell resolution

no code implementations23 Aug 2022 Jialong Jiang, Sisi Chen, Tiffany Tsou, Christopher S. McGinnis, Tahmineh Khazaei, Qin Zhu, Jong H. Park, Paul Rivaud, Inna-Marie Strazhnik, Eric D. Chow, David A. Sivak, Zev J. Gartner, Matt Thomson

We develop a unified mathematical model that quantitatively describes the transcriptome scale response of myeloid and lymphoid cell types to individual drugs and drug combinations through a single inferred regulatory network.

Active Learning of Spin Network Models

1 code implementation25 Mar 2019 Jialong Jiang, David A. Sivak, Matt Thomson

We apply the framework to the inference of spin network models and find that designed perturbations can reduce the sampling complexity by $10^6$-fold across a variety of network architectures.

Active Learning

Optimal control of protein copy number

no code implementations4 Oct 2018 Steven Blaber, David A. Sivak

Cell-cell communication is often achieved by secreted signaling molecules that bind membrane-bound receptors.

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