Search Results for author: Debora Marks

Found 4 papers, 2 papers with code

RITA: a Study on Scaling Up Generative Protein Sequence Models

3 code implementations11 May 2022 Daniel Hesslow, Niccoló Zanichelli, Pascal Notin, Iacopo Poli, Debora Marks

In this work we introduce RITA: a suite of autoregressive generative models for protein sequences, with up to 1. 2 billion parameters, trained on over 280 million protein sequences belonging to the UniRef-100 database.

Protein Design

A generative nonparametric Bayesian model for whole genomes

1 code implementation NeurIPS 2021 Alan Amin, Eli Weinstein, Debora Marks

Generative probabilistic modeling of biological sequences has widespread existing and potential use across biology and biomedicine, particularly given advances in high-throughput sequencing, synthesis and editing.

Density Estimation

Learning Protein Structure with a Differentiable Simulator

no code implementations ICLR 2019 John Ingraham, Adam Riesselman, Chris Sander, Debora Marks

This gap between the expressive capabilities and sampling practicalities of energy-based models is exemplified by the protein folding problem, since energy landscapes underlie contemporary knowledge of protein biophysics but computer simulations are often unable to fold all but the smallest proteins from first-principles.

Protein Folding

Variational Inference for Sparse and Undirected Models

no code implementations ICML 2017 John Ingraham, Debora Marks

Undirected graphical models are applied in genomics, protein structure prediction, and neuroscience to identify sparse interactions that underlie discrete data.

Bayesian Inference Protein Structure Prediction +1

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