Search Results for author: Gašper Tkačik

Found 5 papers, 1 papers with code

Path Weight Sampling: Exact Monte Carlo Computation of the Mutual Information between Stochastic Trajectories

1 code implementation7 Mar 2022 Manuel Reinhardt, Gašper Tkačik, Pieter Rein ten Wolde

The principal idea is to use the master equation to evaluate the exact conditional probability of an individual output trajectory for a given input trajectory, and average this via Monte Carlo sampling in trajectory space to obtain the mutual information.

Eukaryotic gene regulation at equilibrium, or non?

no code implementations13 Oct 2021 Benjamin Zoller, Thomas Gregor, Gašper Tkačik

The key question is therefore how this space can be navigated efficiently, to focus on mechanisms and models that are biologically relevant.

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Statistical modeling of adaptive neural networks explains coexistence of avalanches and oscillations in resting human brain

no code implementations15 Aug 2021 Fabrizio Lombardi, Selver Pepić, Oren Shriki, Gašper Tkačik, Daniele De Martino

Importantly, the inferred parameters correlate with model-independent signatures of "closeness to criticality", indicating that the coexistence of scale-specific (neural oscillations) and scale-free (neuronal avalanches) dynamics in brain activity occurs close to a non-equilibrium critical point at the onset of self-sustained oscillations.

Action at a distance in transcriptional regulation

no code implementations18 Dec 2019 William Bialek, Thomas Gregor, Gašper Tkačik

There is increasing evidence that protein binding to specific sites along DNA can activate the reading out of genetic information without coming into direct physical contact with the gene.

Semiparametric energy-based probabilistic models

no code implementations24 May 2016 Jan Humplik, Gašper Tkačik

Probabilistic models can be defined by an energy function, where the probability of each state is proportional to the exponential of the state's negative energy.

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