Uncovering the dynamic effects of DEX treatment on lung cancer by integrating bioinformatic inference and multiscale modeling of scRNA-seq and proteomics data

no code implementations • 1 Mar 2022 • Minghan Chen, Chunrui Xu, Ziang Xu, wei he, Haorui Zhang, Jing Su, Qianqian Song

Those genes involved in the TGF-\b{eta} pathway and their crosstalk with the ERBB pathway presented a strong survival prognosis in clinical lung cancer samples.

Time Series Analysis

Uncovering the System Vulnerability and Criticality of Human Brain under Dynamical Neuropathological Events in Alzheimer's Disease

no code implementations • 22 Jan 2022 • Jingwen Zhang, Qing Liu, Haorui Zhang, Michelle Dai, Qianqian Song, Defu Yang, Guorong Wu, Minghan Chen

Background: Despite the striking efforts in investigating neurobiological factors behind the acquisition of amyloid-\b{eta} (A), protein tau (T), and neurodegeneration ([N]) biomarkers, the mechanistic pathways of how AT[N] biomarkers spreading throughout the brain remain elusive.