Search Results for author: Xu Steven Xu

Found 9 papers, 0 papers with code

DPSeq: A Novel and Efficient Digital Pathology Classifier for Predicting Cancer Biomarkers using Sequencer Architecture

no code implementations3 May 2023 Min Cen, Xingyu Li, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu

Additionally, under the same experimental conditions using the same set of training and testing datasets, DPSeq surpassed 4 CNN (ResNet18, ResNet50, MobileNetV2, and EfficientNet) and 2 transformer (ViT and Swin-T) models, achieving the highest AUROC and AUPRC values in predicting MSI status, BRAF mutation, and CIMP status.

Time to Embrace Natural Language Processing (NLP)-based Digital Pathology: Benchmarking NLP- and Convolutional Neural Network-based Deep Learning Pipelines

no code implementations21 Feb 2023 Min Cen, Xingyu Li, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu

However, most digital pathology artificial-intelligence models are based on CNN architectures, probably owing to a lack of data regarding NLP models for pathology images.

Benchmarking whole slide images

Prognostic Significance of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images in Colorectal Cancers

no code implementations23 Aug 2022 Anran Liu, Xingyu Li, Hongyi Wu, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu

Methods We developed an automated, multiscale LinkNet workflow for quantifying cellular-level TILs for CRC tumors using H&E-stained images.

Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E-stained images: Achieving SOTA predictive performance with fewer data using Swin Transformer

no code implementations22 Aug 2022 Bangwei Guo, Xingyu Li, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu

In this study, based on the latest Hierarchical Vision Transformer using Shifted Windows (Swin-T), we developed an efficient workflow for biomarkers in CRC (MSI, hypermutation, chromosomal instability, CpG island methylator phenotype, BRAF, and TP53 mutation) that only required relatively small datasets, but achieved the state-of-the-art (SOTA) predictive performance.

A robust and lightweight deep attention multiple instance learning algorithm for predicting genetic alterations

no code implementations31 May 2022 Bangwei Guo, Xingyu Li, Miaomiao Yang, Hong Zhang, Xu Steven Xu

In addition, compared to the published models for genetic alterations, AMIML provided a significant improvement for predicting a wide range of genes (e. g., KMT2C, TP53, and SETD2 for KIRC; ERBB2, BRCA1, and BRCA2 for BRCA; JAK1, POLE, and MTOR for UCEC) as well as produced outstanding predictive models for other clinically relevant gene mutations, which have not been reported in the current literature.

Deep Attention Multiple Instance Learning

Colorectal cancer survival prediction using deep distribution based multiple-instance learning

no code implementations24 Apr 2022 Xingyu Li, Jitendra Jonnagaddala, Min Cen, Hong Zhang, Xu Steven Xu

Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs). However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease progression is difficult for both clinicians, and deep learning algorithms.

Multiple Instance Learning Survival Prediction +1

Optimize Deep Learning Models for Prediction of Gene Mutations Using Unsupervised Clustering

no code implementations31 Mar 2022 Zihan Chen, Xingyu Li, Miaomiao Yang, Hong Zhang, Xu Steven Xu

We showed that unsupervised clustering of image patches could help identify predictive patches, exclude patches lack of predictive information, and therefore improve prediction on gene mutations in all three different cancer types, compared with the WSI based method without selection of image patches and models based on only tumor regions.

Clustering Multiple Instance Learning

Improving Feature Extraction from Histopathological Images Through A Fine-tuning ImageNet Model

no code implementations3 Jan 2022 Xingyu Li, Min Cen, Jinfeng Xu, Hong Zhang, Xu Steven Xu

The extracted features from the finetuned FTX2048 exhibited significantly higher accuracy for predicting tisue types of CRC compared to the off the shelf feature directly from Xception based on ImageNet database.

Transfer Learning

A Retrospective Analysis using Deep-Learning Models for Prediction of Survival Outcome and Benefit of Adjuvant Chemotherapy in Stage II/III Colorectal Cancer

no code implementations5 Nov 2021 Xingyu Li, Jitendra Jonnagaddala, Shuhua Yang, Hong Zhang, Xu Steven Xu

We developed a novel deep-learning algorithm (CRCNet) using whole-slide images from Molecular and Cellular Oncology (MCO) to predict survival benefit of adjuvant chemotherapy in stage II/III CRC.

whole slide images

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