no code implementations • 3 May 2023 • Min Cen, Xingyu Li, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu
Additionally, under the same experimental conditions using the same set of training and testing datasets, DPSeq surpassed 4 CNN (ResNet18, ResNet50, MobileNetV2, and EfficientNet) and 2 transformer (ViT and Swin-T) models, achieving the highest AUROC and AUPRC values in predicting MSI status, BRAF mutation, and CIMP status.
no code implementations • 21 Feb 2023 • Min Cen, Xingyu Li, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu
However, most digital pathology artificial-intelligence models are based on CNN architectures, probably owing to a lack of data regarding NLP models for pathology images.
no code implementations • 23 Aug 2022 • Anran Liu, Xingyu Li, Hongyi Wu, Bangwei Guo, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu
Methods We developed an automated, multiscale LinkNet workflow for quantifying cellular-level TILs for CRC tumors using H&E-stained images.
no code implementations • 22 Aug 2022 • Bangwei Guo, Xingyu Li, Jitendra Jonnagaddala, Hong Zhang, Xu Steven Xu
In this study, based on the latest Hierarchical Vision Transformer using Shifted Windows (Swin-T), we developed an efficient workflow for biomarkers in CRC (MSI, hypermutation, chromosomal instability, CpG island methylator phenotype, BRAF, and TP53 mutation) that only required relatively small datasets, but achieved the state-of-the-art (SOTA) predictive performance.
no code implementations • 31 May 2022 • Bangwei Guo, Xingyu Li, Miaomiao Yang, Hong Zhang, Xu Steven Xu
In addition, compared to the published models for genetic alterations, AMIML provided a significant improvement for predicting a wide range of genes (e. g., KMT2C, TP53, and SETD2 for KIRC; ERBB2, BRCA1, and BRCA2 for BRCA; JAK1, POLE, and MTOR for UCEC) as well as produced outstanding predictive models for other clinically relevant gene mutations, which have not been reported in the current literature.
no code implementations • 24 Apr 2022 • Xingyu Li, Jitendra Jonnagaddala, Min Cen, Hong Zhang, Xu Steven Xu
Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs). However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease progression is difficult for both clinicians, and deep learning algorithms.
no code implementations • 31 Mar 2022 • Zihan Chen, Xingyu Li, Miaomiao Yang, Hong Zhang, Xu Steven Xu
We showed that unsupervised clustering of image patches could help identify predictive patches, exclude patches lack of predictive information, and therefore improve prediction on gene mutations in all three different cancer types, compared with the WSI based method without selection of image patches and models based on only tumor regions.
no code implementations • 3 Jan 2022 • Xingyu Li, Min Cen, Jinfeng Xu, Hong Zhang, Xu Steven Xu
The extracted features from the finetuned FTX2048 exhibited significantly higher accuracy for predicting tisue types of CRC compared to the off the shelf feature directly from Xception based on ImageNet database.
no code implementations • 5 Nov 2021 • Xingyu Li, Jitendra Jonnagaddala, Shuhua Yang, Hong Zhang, Xu Steven Xu
We developed a novel deep-learning algorithm (CRCNet) using whole-slide images from Molecular and Cellular Oncology (MCO) to predict survival benefit of adjuvant chemotherapy in stage II/III CRC.