Transcriptional Response of SK-N-AS Cells to Methamidophos

11 Aug 2019Akos VertesAlbert-Baskar ArulPeter AvarAndrew R. KorteLida ParvinZiad J. SahabDeborah I. BuninMerrill KnappDenise NishitaAndrew PoggioMark-Oliver StehrCarolyn L. TalcottBrian M. DavisChristine A. MortonChristopher J. SevinskyMaria I. Zavodszky

Transcriptomics response of SK-N-AS cells to methamidophos (an acetylcholine esterase inhibitor) exposure was measured at 10 time points between 0.5 and 48 h. The data was analyzed using a combination of traditional statistical methods and novel machine learning algorithms for detecting anomalous behavior and infer causal relations between time profiles. We identified several processes that appeared to be upregulated in cells treated with methamidophos including: unfolded protein response, response to cAMP, calcium ion response, and cell-cell signaling... (read more)

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